Search results for " nitrates"

Imbalance Between Oxidative Stress and Growth Factors in Human High Myopia.

2020

Este artículo se encuentra disponible en la siguiente URL: https://www.frontiersin.org/articles/10.3389/fphys.2020.00463/full Myopia is one of the commonest eye pathologies that could affect 2.56 billion people by 2020. Today high myopia is a leading cause of blindness worldwide due to associated ocular illness. Nevertheless, the cellular bases for these diseases to develop are unclear in many areas. We conducted a prospective study of oxidative stress and growth factors in human myopic and non myopic eyes in an attempt to increase our understanding of the underlying physiopathological conditions to adequately early diagnose, prevent and treat the retina problem that derives from myopia. Aq…

Phosphodiesterase-5 Inhibition Alleviates Pulmonary Hypertension and Basal Lamina Thickening in Rats Challenged by Chronic Hypoxia

2018

javax.xml.bind.JAXBElement@6f8948ff Hypoxia represents both an outcome of cardiopulmonary diseases and a trigger for severe pulmonary complications as pulmonary hypertension. Because nitric oxide (NO) is a critical mediator in the development of pulmonary hypertension, the modulators of its downstream function may become target of pharmacological interventions aimed at alleviating the impact of this condition. Here, we investigate the effects of an early administration of phosphodiesterase-5 inhibitor in rats where pulmonary artery hypertension was induced by chronic exposure to hypoxia. javax.xml.bind.JAXBElement@162dc677 Rats were divided into three groups: normoxic control, hypoxic with …

Tolerance to nitroglycerin-induced preconditioning of the endothelium: a human in vivo study

2009

Damage and dysfunction of the vascular endothelium critically influence clinical outcomes after ischemia and reperfusion (I/R). Brief exposure to organic nitrates can protect the vascular endothelium from I/R injury via a mechanism that is similar to ischemic preconditioning and is independent of hemodynamic changes. The clinical relevance of these protective effects clearly depends on whether they can be sustained over time. Twenty-four healthy (age 25–32) male volunteers were randomized to receive 1) transdermal nitroglycerin (GTN; 0.6 mg/h) administered for 2 h on 1 day only, 2) transdermal GTN for 2 h/day for 7 days, or 3) continuous therapy with transdermal GTN for 7 days. Eight volunt…

Three-Dimensional Calibration for Routine Analyses of Bromide and Nitrate Ions as Indicators of Groundwater Quality in Coastal Territories

2019

Nitrate and bromide ions are generally considered indicators of anthropogenic pollution and seawater intrusion, respectively, in the groundwater of coastal territories. The analysis of these species is generally carried out with routine chromatographic analyses which generally afford partially merged or poorly resolved peaks. In the present paper a simple method for the correct evaluation of their concentration in water is reported. This method does not imply utilization of other instruments or technologies, only the mathematical elaboration of the data obtained from routine analysis of standard solutions containing the two species. Standard binary solutions of nitrate and bromide ions at d…

P105. New findings on vasodilator potency, tachyphylaxis, and bioavailability of organic nitrates reveal: The tolerance-devoid clinical action of pen…

2006

Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress

2007

Citrate-nitrate auto-combustion synthesis of perovskite-type nanopowders: A systematic approach

2009

In vitro and in vivo characterization of a new organic nitrate hybrid drug covalently bound to pioglitazone.

2014

<b><i>Background/Aims:</i></b> Organic nitrates represent a group of nitrovasodilators that are clinically used for the treatment of ischemic heart disease. The new compound CLC-3000 is an aminoethyl nitrate (AEN) derivative of pioglitazone, a thiazolidinedione antidiabetic agent combining the peroxisome proliferator-activated receptor γ agonist activity of pioglitazone with the NO-donating activity of the nitrate moiety. <b><i>Methods:</i></b> In vitro and in vivo characterization was performed by isometric tension recording, platelet function, bleeding time and detection of oxidative stress. <b><i>Results:</i></…

Effetti delle epoche e modalità di concimazione su produzione e qualità del finocchio. Effects of time and method of fertilizer application on yield …

2010

Two field trials were carried out in Sicily during fall-winter and spring season to determine the influence of 9 fertilization treatments, obtained by changing the time (pre-plant and/or post-plant fertilization), and method (broadcast fertilization and/or fertigation) of fertilizer application and the type of fertilizer (mineral, organic, slow release fertilizers) on yield and quality of fennel. An unfertilized treatment (control) was also included. In all fertilized treatments, macronutrients were applied at the following total rates (kg ha-1): N (350), P2O5 (100), K2O (208). In both trials the highest yield and mean bulb weight was obtained by pre-planting application of all mineral fert…

Comments on 'formation and characterization of nanotubes of La(OH) 3 obtained using porous alumina membranes'

2010

New experimental evidence concerning the formation of La(OH)3 nanowires on anodic alumina membranes by cathodic polarization in 0.05 M lanthanum nitrate solution is provided to further support the conclusions previously reached in our work (Bocchetta et al 2007 Electrochem. Commun. 9 683-8) and recently criticized by González-Rovira et al (Nanotechnology 2008 19 495305). Some unconvincing aspects of the paper of González-Rovira et al, according to which the same electrochemical process should lead to the formation of hydroxycarbonate nanotubes, are also discussed.